Nitrofurantoin PK values were obtained from studies using many variables, e.g. The current body of PK knowledge of both drugs appears to be poor and mainly based on old studies. The aims of this review were to (i) summarize the PK data reported in the literature and (ii) to identify PK knowledge gaps. New interest in both these drugs is increasing because of the emergence of resistance to other antibiotics, but knowledge of their pharmacokinetics (PK) is lacking since they were developed before the advent of standardized research for drug approval. Nitrofurantoin and nitroxoline are oral antibiotics for the treatment or prophylaxis of acute urinary tract infections.
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